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14-3-3 beta/YWHAB  抗体

All YWHAB Reagents

反应性: Human  
应用 : FCM  
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10843-MM03-F-25
10843-MM03-F-100
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100 Tests 
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反应性: Human  
应用 : FCM  
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10843-MM03-P-25
10843-MM03-P-100
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100 Tests 
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反应性: Human  
应用 : ELISA  WB  IP  
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10843-RP02-50
10843-RP02-200
10843-RP02-100
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200 µg 
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反应性: Human  
应用 : FCM  
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10843-MM03-A-25
10843-MM03-A-100
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100 Tests 
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反应性: Human  
应用 : ELISA  FCM  IF  ICC/IF  
  • Slide 1
  • Slide 1
10843-MM03-50
10843-MM03-200
10843-MM03-100
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200 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    10843-RP01-400
    10843-RP01-200
    10843-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : FCM  
    • Slide 1
    10843-MM03-C-25
    10843-MM03-C-100
    25 Test 
    100 Tests 
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    反应性: Cynomolgus  
    应用 : 
    • Slide 1
    90022-T36-50
    90022-T36-200
    90022-T36-100
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    200 µg 
    100 µg 
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    反应性: Cynomolgus  
    应用 : ELISA  WB  IP  
    • Slide 1
    • Slide 1
    90022-MM05-50
    90022-MM05-200
    90022-MM05-100
    50 µg 
    200 µg 
    100 µg 
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    14-3-3 beta/YWHAB 相关研究领域

    14-3-3 beta/YWHAB 相关信号通路

    14-3-3 beta/YWHAB 概述&蛋白信息

    14-3-3 beta/YWHAB 研究背景

    基因概述: YWHAB gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for YWHAB gene. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    亚单位结构: Homodimer. Interacts with SAMSN1 and PRKCE (By similarity). Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C and SIRT2. Interacts with herpes simplex virus 1 protein UL46. {ECO:0000250, ECO:0000269|PubMed:11427721, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:17085597, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18249187, ECO:0000269|PubMed:19172738, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:23938468, ECO:0000269|PubMed:24636949}.
    亚细胞定位: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    翻译后修饰: The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. {ECO:0000250}.; Isoform Short contains a N-acetylmethionine at position 1. {ECO:0000250}.
    相似的序列: Belongs to the 14-3-3 family. {ECO:0000305}.
    General information above from UniProt

    14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

    14-3-3 beta/YWHAB 别称

    HS1,GW128,YWHAA,KCIP-1,HEL-S-1, [homo-sapiens]
    HS1,14-3-3 protein beta,GW128,KCIP-1,YWHAB, [human]
    1300003C17Rik,14-3-3 protein beta,RP23-321M14.1,Ywhab, [mouse]
    1300003C17Rik, [mus-musculus]

    14-3-3 beta/YWHAB 相关文献

  • Tommerup N, et al. (1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50.
  • Jin YH, et al. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5.
  • Sekimoto T, et al. (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.
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