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14-3-3 sigma / Stratifin / YWHAS / SFN 抗体, 兔多抗, 抗原亲和纯化

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     YWHAS/SFN 抗体产品信息
    免疫原:Recombinant Human 14-3-3 sigma / Stratifin / YWHAS / SFN protein (Catalog#10998-H08H)
    克隆号:
    Ig 类型:Rabbit IgG
    浓度:
    缓冲液:0.2 μm filtered solution in PBS with 5% trehalose
    抗体制备方法:Produced in rabbits immunized with purified, recombinant Human 14-3-3 sigma / Stratifin / YWHAS / SFN (rh 14-3-3 sigma / Stratifin / YWHAS / SFN; Catalog#10838-HNCE; NP_006133.1; Met 1-Ser 248). 14-3-3 sigma / Stratifin / YWHAS / SFN specific IgG was purified by Human 14-3-3 sigma / Stratifin / YWHAS / SFN affinity chromatography.
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    14-3-3 sigma/Stratifin/YWHAS 研究背景

    14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

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