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2B4 / CD244  基因

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2B4 / CD244 相关研究领域

2B4 / CD244 相关信号通路

    2B4 / CD244 概述&蛋白信息

    2B4 / CD244 研究背景

    基因概述: This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
    General information above from NCBI
    亚单位结构: Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2. {ECO:0000269|PubMed:10359122, ECO:0000269|PubMed:10458320, ECO:0000269|PubMed:10556801}.
    亚细胞定位: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
    组织特异性: Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils. {ECO:0000269|PubMed:10556801}.
    翻译后修饰: N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding. {ECO:0000269|PubMed:21606496}.
    相似的序列: Contains 2 Ig-like (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    The CD244 antigen

    2B4 / CD244 别称

    2B4 / CD244 相关文献

  • Nakajima H, et al. (2000) 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism. Hum Immunol. 61(1): 39-43.
  • Chuang SS, et al. (2001) 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. J Immunol. 167(11): 6210-6.
  • McNerney ME, et al. (2005) 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol Immunol. 42(4): 489-94.
  • Mathew SO, et al. (2009) Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 39(6): 1632-41.
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