4-1BBL cDNA ORF Clone in Cloning Vector, Mouse

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4-1BBL cDNA ORF Clone in Cloning Vector, Mouse: 基本信息

基因
种属
Mouse
NCBI 参考序列号
参考序列ORF长度
930 bp
序列描述
Identical with the Gene Bank Ref. ID sequence except for the point mutation 309C/T not causing the amino acid variation.
描述
Full length Clone DNA of Mouse tumor necrosis factor (ligand) superfamily, member 9.
质粒
测序引物
M13-47 and RV-M
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Ampicillin
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

4-1BBL cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

4-1BBL cDNA ORF Clone in Cloning Vector, Mouse: Alternative Names

4-1BB-L cDNA ORF Clone, Mouse; 4-1BBL cDNA ORF Clone, Mouse; AI848817 cDNA ORF Clone, Mouse; Cd137l cDNA ORF Clone, Mouse; Ly63l cDNA ORF Clone, Mouse

4-1BBL Background Information

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.Immune Checkpoint
Immune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: FCM Antibodies
Immune Checkpoint TargetsCo-stimulatory Immune Checkpoint Targets ImmunotherapyCancer ImmunotherapyTargeted Therapy
Full Name
tumor necrosis factor (ligand) superfamily, member 9
References
  • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
  • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
  • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.

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