ABCA9: ABCA9 Protein | ABCA9 Antibody

ABCA9 Gene family

ABCA9 Protein

ABCA9 protein function

May play a role in monocyte differentiation and lipid homeostasis.

ABCA9 protein expression

Tissue specificity

Widely expressed with higher expression in heart.

Induction

Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.

ABCA9 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,624.00
  • Mass (Da)
    184.00

ABCA9 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]