ABCB1: ABCB1 Protein | ABCB1 Antibody

ABCB1 Gene family

ABCB1 Protein

ABCB1 protein function

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

ABCB1 protein expression

Tissue specificity

Expressed in liver, kidney, small intestine and brain.

ABCB1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,280.00
  • Mass (Da)
    141.00

ABCB1 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]