快速订购

相关家族成员
Protein Wiki by Initials

ABCB1

ABCB1 蛋白&抗体

Entrez Gene Summary for ABCB1基因Entrez概述


OMIM-Description for ABCB1OMIM概述


A cDNA encoding p170, a glycoprotein that is increased in membranes from multidrug-resistant cells (including the ones used by Fojo et al. (1986)) was cloned by Riordan et al. (1985). Roninson et al. (1986) found that multidrug resistance correlated with amplification of 2 related DNA sequences, designated MDR1 and MDR2 (MDR2 has been referred to by others as MDR3; see 171060). These sequences were isolated through their homology with the Chinese hamster mdr gene. MDR1 encodes a 4.5-kb mRNA and was amplified or overexpressed in all multidrug-resistant human cell lines analyzed. No mRNA corresponding to MDR2 was detected. MDR2 DNA sequences are coamplified with MDR1 in some but not all multidrug-resistant cell lines. Ueda et al. (1986) confirmed that the MDR1 gene codes for P-glycoprotein. Gros et al. (1986) isolated a cDNA that on transfer to an otherwise drug-sensitive cell conferred a complete multidrug-resistant phenotype. Since the cDNA was isolated from a drug-sensitive cell, mutations in the primary sequence of MDR were not required to produce multidrug resistance; thus, amplification is the mechanism of the resistance. Chen et al. (1986) and Gros et al. (1986) found that the class of mammalian membrane glycoproteins implicated in the phenomenon of multidrug resistance in tumor cells bears strong homology to a class of well-studied bacterial transport proteins. Chen et al. (1986) reported the sequence of the MDR cDNA of the human and Gros et al. (1986) reported that of the mouse.

.zh= 维基百科概述ABCB1


P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances.

ABCB1 别称

ABCB1 Related Products

ABCB1 Proteins

Product nameProduct name

ABCB1 Antibodies

Product nameProduct name

ABCB1 cDNA Clones

Product nameProduct name
人 ABCB1 基因ORF全长cDNA克隆(表达载体), N-HA 标签人 ABCB1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签人 ABCB1 基因ORF全长cDNA克隆(表达载体)人 ABCB1 基因ORF全长cDNA(克隆载体)

ABCB1 ELISA

Product nameProduct name
请注意:所有产品都是“仅用于科研,而不是为了用于诊断或治疗用途”