Anti-BCRP / ABCG2 Antibody

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Anti-BCRP / ABCG2 Antibody (Rabbit Polyclonal 抗体) 产品信息

产品名称
Anti-BCRP / ABCG2 Antibody
经验证的应用
WB,IP
交叉反应
Reacts with: Human
特异性
Human BCRP / ABCG2
免疫原
A synthetic peptide corresponding to the N-terminus of the Human ABCG2
制备方法
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human ABCG2, and purified by antigen affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-BCRP / ABCG2 Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
WB 1:500-1:2000
IP 1-4 μL/mg of lysate
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-BCRP / ABCG2 Antibody (Rabbit Polyclonal 抗体) 图片

ABCG2 was immunoprecipitated using:

Lane A:0.5 mg Jurkat Whole Cell Lysate

2 µL anti-ABCG2 rabbit polyclonal antibody and 60 μg of Immunomagnetic beads Protein G.

Primary antibody:

Anti-ABCG2 rabbit polyclonal antibody,at 1:100 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 70 kDa

Observed band size: 70 kDa

Anti-ABCG2 rabbit polyclonal antibody at 1:500 dilution

Lane A: HepG2 Whole Cell Lysate

Lane B: Jurkat Whole Cell Lysate

Lane C: cos-7 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:72 kDa

Observed band size:70 kDa

Anti-BCRP / ABCG2 Antibody: 别称

Anti-ABC15 Antibody; Anti-ABCP Antibody; Anti-BCRP Antibody; Anti-BCRP1 Antibody; Anti-BMDP Antibody; Anti-CD338 Antibody; Anti-CDw338 Antibody; Anti-EST157481 Antibody; Anti-GOUT1 Antibody; Anti-MRX Antibody; Anti-MXR Antibody; Anti-MXR1 Antibody; Anti-UAQTL1 Antibody

BCRP / ABCG2 背景信息

ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins. the expression of ABCG2 is related to tumorigenic cancer stem cells (CSC) in several cancers, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and decreasing their intracellular accumulation. ABCB1 and ABCG2 are efflux transporters which have a major impact on the pharmacological behavior of numerous drugs. They are expressed in the intestine, liver, kidney, BBB and placenta. It has become evident that ABCB1 and ABCG2 modify the pharmaco/toxicokinetics in the placenta and fetus and may consequently affect the outcome of pregnancy.
全称
ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
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