ABHD14A: ABHD14A Protein | ABHD14A Antibody

ABHD14A Gene family

ABHD14A Protein

ABHD14A protein function

Possible role in granule neuron development.

ABHD14A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    271.00
  • Mass (Da)
    29.00

ABHD14A Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]