All ACVR2B reagents are produced in house and quality controlled, including 8 ACVR2B Antibody, 26 ACVR2B Gene, 1 ACVR2B IPKit, 7 ACVR2B Lysate, 7 ACVR2B Protein, 2 ACVR2B qPCR. All ACVR2B reagents are ready to use.
Recombinant ACVR2B proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc & His, C-human IgG1-Fc, C-His, C-cleavage.
ACVR2Bantibodies are validated with different applications, which are ELISA, IP, WB, IHC-P.
ACVR2BcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ACVR2B of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.