ACVR2B cDNA ORF Clone, Human, C-DDK (Flag®) tag

Cat: HG10229-M-F

NOT AVAILABLE

Contact us:
215-583-7898
order@sinobiological.com
Distributors
All ACVR2B Reagents
CRO Services

All ACVR2B Reagents
ACVR2B cDNA ORF Clone, Human, C-DDK (Flag®) tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
1539 bp
序列描述
Identical with the Gene Bank Ref. ID sequence except for two point mutations: 333 A/G and 1458 C/T, neither of which results in the amino acid substitution.
描述
Full length Clone DNA of Human activin A receptor, type I IB with Flag tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV2-FLAG
限制性酶切位点
KpnI + XbaI (5.4kb + 1.59kb)
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.
ACVR2B cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ACVR2B cDNA ORF Clone, Human, C-DDK (Flag®) tag Alternative Names
Activin RIIB cDNA ORF Clone, Human;ActR-IIB cDNA ORF Clone, Human;ACTRIIB cDNA ORF Clone, Human;HTX4 cDNA ORF Clone, Human
ACVR2B Background Information

ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

Full Name
activin A receptor, type IIB
References
  • Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
  • Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
  • Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
  • Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.
  • ACVR2B cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    ACVR2B cDNA ORF Clone in Cloning Vector, Mouse MG50173-M
    ACVR2B cDNA ORF Clone, Mouse, untagged MG50173-UT
    ACVR2B cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50173-ACG
    ACVR2B Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50173-ACGLN
    ACVR2B cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50173-ACR
    ACVR2B cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50173-CF
    ACVR2B cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50173-NF
    ACVR2B cDNA ORF Clone, Mouse, C-His tag MG50173-CH
    ACVR2B cDNA ORF Clone, Mouse, N-His tag MG50173-NH
    ACVR2B cDNA ORF Clone, Mouse, C-HA tag MG50173-CY
    ACVR2B cDNA ORF Clone, Mouse, N-HA tag MG50173-NY
    ACVR2B cDNA ORF Clone, Mouse, C-Myc tag MG50173-CM
    ACVR2B cDNA ORF Clone, Mouse, N-Myc tag MG50173-NM
    ACVR2B qPCR Primer Pairs, Mouse MP200203

    ACVR2B cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    ACVR2B cDNA ORF Clone in Cloning Vector, Human HG10229-M
    ACVR2B cDNA ORF Clone, Human, untagged HG10229-UT
    ACVR2B cDNA ORF Clone, Human, C-GFPSpark® tag HG10229-ACG
    ACVR2B Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10229-ACGLN
    ACVR2B cDNA ORF Clone, Human, C-OFPSpark® tag HG10229-ACR
    ACVR2B cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10229-CF
    ACVR2B cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10229-NF
    ACVR2B cDNA ORF Clone, Human, C-His tag HG10229-CH
    ACVR2B cDNA ORF Clone, Human, N-His tag HG10229-NH
    ACVR2B cDNA ORF Clone, Human, C-HA tag HG10229-CY
    ACVR2B cDNA ORF Clone, Human, N-HA tag HG10229-NY
    ACVR2B cDNA ORF Clone, Human, C-Myc tag HG10229-CM
    ACVR2B cDNA ORF Clone, Human, N-Myc tag HG10229-NM
    ACVR2B qPCR Primer Pairs, Human HP100284
    info info
    添加购物车成功! 添加购物车失败!