All Adenosine Receptor A2a reagents are produced in house and quality controlled, including 27 Adenosine Receptor A2a Gene, 2 Adenosine Receptor A2a qPCR. All Adenosine Receptor A2a reagents are ready to use.
Adenosine Receptor A2a cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Adenosine Receptor A2a of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.Immune Checkpoint Immune Checkpoint TargetsCo-inhibitory Immune Checkpoint TargetsImmunotherapyCancer ImmunotherapyTargeted Therapy
Adenosine Receptor A2a References
Alchera E, Imarisio C, Mandili G, et al. Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype. BioMed Research International. 2015;2015:286746.