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AK2 / Adenylate kinase 2 抗体, 兔单抗

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 AK2 抗体产品信息
免疫原:Recombinant Human AK2 protein (Catalog#13146-H20B)
克隆号:025
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS with 5% trehalose
抗体制备方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human AK2 (rh AK2; Catalog#13146-H20B; P54819-1; Met1-Ile239).
 AK2 抗体WB实验图片
 AK2 抗体IHC实验图片
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human AK2 in human kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human AK2 in human liver with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
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AK2 / Adenylate kinase 2 研究背景

Adenylate kinase 2 (AK2) belongs to the Adenylate kinase family that contains three isozymes: AK1, AK2 and AK3. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Adenylate kinase2 (AK2) is expressed in mitochondrial intermembrane space. It may play a role in apoptosis. It has been demonstrated that in apoptotic cells AK2 was translocated into the cytosol concomitantly with cytochronme C. Mutations in this gene are the cause of reticular dysgenesis. These mutations result in absent or strongly decreased protein expression. It has been also established that AK2 is specifically expressed in the stria vascularis region of the inner ear, which provides an explanation of the sensorineural deafness in these individuals. 

 AK2 / Adenylate kinase 2 参考资料
  • Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106-11.
  • Bruns GA, et al. (1977) Adenylate kinase 2, a mitochondrial enzyme. Biochem Genet. 15 (5-6): 477-86.
  • Khler C, et al. (1999) Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett. 447 (1): 10-2.
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    货号: 13146-R025-50
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    • AK2 / Adenylate kinase 2 Antibody, Rabbit MAb
    • AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
    • AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
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