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AKT2/PKB beta  蛋白

All AKT2 Reagents

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表达宿主: Baculovirus-Insect Cells  
10764-H20B-50
10764-H20B-20
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AKT2/PKB beta 相关研究领域

AKT2/PKB beta 概述&蛋白信息

AKT2/PKB beta 研究背景

催化活性: ATP + a protein = ADP + a phosphoprotein.
酶调控: ENZYME REGULATION: Two specific sites, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation. Aminofurazans are potent AKT2 inhibitors. {ECO:0000269|PubMed:18800763, ECO:0000269|PubMed:19179070}.
亚单位结构: Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CLK2, PBH2 and TRAF6. Interacts (when phosphorylated) with CLIP3, the interaction promotes cell membrane localization (PubMed:19139280). {ECO:0000250|UniProtKB:Q60823, ECO:0000269|PubMed:10983986, ECO:0000269|PubMed:12434148, ECO:0000269|PubMed:17565718, ECO:0000269|PubMed:19139280, ECO:0000269|PubMed:19713527, ECO:0000269|PubMed:21737686}.
结构域: Binding of the PH domain to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) following phosphatidylinositol 3-kinase alpha (PIK3CA) activity results in its targeting to the plasma membrane.
亚细胞定位: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3.
组织特异性: Expressed in all cell types so far analyzed.
翻译后修饰: Phosphorylation on Thr-309 and Ser-474 is required for full activity. {ECO:0000269|PubMed:12434148, ECO:0000269|PubMed:15890450, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:9512493}.; Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT2 ubiquitination. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome. {ECO:0000269|PubMed:19713527, ECO:0000269|PubMed:20059950}.; O-GlcNAcylation at Thr-306 and Thr-313 inhibits activating phosphorylation at Thr-309 via disrupting the interaction between AKT and PDK1. {ECO:0000250}.
相关疾病 : DISEASE: Note=Defects in AKT2 are a cause of susceptibility to breast cancer (BC). AKT2 promotes metastasis of tumor cells without affecting the latency of tumor development. With AKT3, plays also a pivotal role in the biology of glioblastoma.; DISEASE: Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:15166380, ECO:0000269|PubMed:19164855}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Hypoinsulinemic hypoglycemia with hemihypertrophy (HIHGHH) [MIM:240900]: A disorder characterized by hypoglycemia, low insulin levels, low serum levels of ketone bodies and branched-chain amino acids, left-sided hemihypertrophy, neonatal macrosomia, reduced consciousness and hypoglycemic seizures. {ECO:0000269|PubMed:21979934}. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似的序列: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. {ECO:0000305}.; Contains 1 AGC-kinase C-terminal domain. {ECO:0000305}.; Contains 1 PH domain. {ECO:0000255|PROSITE-ProRule:PRU00145}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

AKT2/PKB beta 别称

PKBB,PRKBB,HIHGHH,PKBBETA,RAC-BETA, [homo-sapiens]
HIHGHH ,PKBB,PKBBETA,PRKBB,RAC-BETA, [Human]
2410016A19Rik,AW554154,PKBbeta, [mouse]
PKB,PKBbeta,AW554154,2410016A19Rik, [mus-musculus]

AKT2/PKB beta 相关文献

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