ANGPTL5 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All ANGPTL5 reagents are produced in house and quality controlled, including 1 ANGPTL5 Lysate, 1 ANGPTL5 Protein. All ANGPTL5 reagents are ready to use.

ANGPTL5 Protein (1)

ANGPTL5 Lysate (1)

ANGPTL5 分子背景

The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels from pre-existing blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. In addition, there are a number of proteins that are closely related to angiopoietins (ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL5, ANGPTL6, ANGPTL7). Angiopoietin-like 5 (ANGPTL5) is mainly expressed in adult heart. Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. ANGPTL5 are regulators of lipoprotein metabolism in humans. ANGPTL5 plays nonredundant roles in TG metabolism, and multiple alleles at these loci cumulatively contribute to variability in plasma TG levels in humans.

ANGPTL5 参考文献

  • Miida T, et al. (2010) Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events. Curr Opin Lipidol. 21(1): 70-5.
  • Romeo S, et al. (2009) Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J Clin Invest. 119(1): 70-9.
  • Zeng L, et al. (2003) Identification of a novel human angiopoietin-like gene expressed mainly in heart. J Hum Genet. 48(3): 159-62.