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ANTXR2 / CMG2  蛋白

All ANTXR2 Reagents

表达宿主: Human Cells  
  • Slide 1
15762-H02H-100
15762-H02H-50
100 µg 
50 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
51131-M02H-50
51131-M02H-100
50 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
51131-M08H-50
51131-M08H-100
50 µg 
100 µg 
Add to Cart

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ANTXR2 / CMG2 相关信号通路

ANTXR2 / CMG2 概述&蛋白信息

ANTXR2 / CMG2 研究背景

亚单位结构: Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner, with the following preference: calcium > manganese > magnesium > zinc. Binding of PA leads to heptamerization of the receptor-PA complex.
结构域: Binding to PA seems to be effected through the VWA domain.
亚细胞定位: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface.
Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
Isoform 3: Secreted.
组织特异性: Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
相关疾病 : Hyaline fibromatosis syndrome (HFS) [MIM:228600]: An autosomal recessive syndrome characterized by abnormal growth of hyalinized fibrous tissue usually affecting subcutaneous regions on the scalp, ears, neck, face, hands, and feet. The lesions appear as pearly papules or fleshy nodules. Additional features include gingival hypertrophy, progressive joint contractures resulting in severe limitation of mobility, osteopenia, and osteoporosis. Disease severity is variable. Some individuals manifest symptoms in infancy and have additional visceral or systemic involvement. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to early death. Surviving children may suffer from severely reduced mobility due to joint contractures. Other patients have later onset of a milder disorder affecting only the face and digits. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似的序列: Belongs to the ATR family.
Contains 1 VWFA domain.
General information above from UniProt

ANTXR2 / CMG2 别称

HFS,ISH,JHF,CMG2,CMG-2, [homo-sapiens]
anthrax toxin receptor 2,ANTXR2,CMG-2,CMG2,HFS,ISH,JHF,capillary morphogenesis gene 2 protein,capillary morphogenesis protein 2, [human]
anthrax toxin receptor 2,Antxr2,2310046B19Rik,AW561899,CMG-2,CMG2,cI-35, [mouse]
CMG2,CMG-2,cI-35,AW561899,2310046B19Rik, [mus-musculus]

ANTXR2 / CMG2 相关文献

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