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ATCAY  蛋白,抗体,试剂盒,cDNA克隆

ATCAY 相关研究领域

ATCAY 相关信号通路

    ATCAY 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    ATCAY 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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    ATCAY 概述&蛋白信息

    ATCAY 研究背景

    亚单位结构: Interacts with KLC1; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections (By similarity). Interacts with GLS; the interaction is direct and may control GLS localization, negatively regulating its activity. Interacts with PIN1 (via WW domain); upon NGF stimulation. The interaction with PIN1 and GLS is competitive. May interact with MAP2K2. {ECO:0000250, ECO:0000269|PubMed:16899818, ECO:0000269|PubMed:18628984, ECO:0000269|PubMed:21369758}.
    结构域: The CRAL-TRIO domain is known to bind small hydrophobic molecules. {ECO:0000250}.
    亚细胞定位: Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:16899818}. Mitochondrion envelope {ECO:0000269|PubMed:16899818}. Note=Localizes presynaptically into neuron projections.
    翻译后修饰: Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2. {ECO:0000269|PubMed:21369758}.; May be ubiquitinated by STUB1. {ECO:0000269|PubMed:16275660}.
    相关疾病 : DISEASE: Cerebellar ataxia, cayman type (ATCAY) [MIM:601238]: Found in a population isolate on Grand Cayman Island and causes a marked psychomotor retardation and prominent nonprogressive cerebellar dysfunction including nystagmus, intention tremor, dysarthria, and wide-based ataxic gait. Hypotonia is present from early childhood. {ECO:0000269|PubMed:14556008}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Contains 1 CRAL-TRIO domain. {ECO:0000255|PROSITE-ProRule:PRU00056}.
    General information above from UniProt

    ATCAY 别称

    CLAC,BNIP-H, [homo-sapiens]
    ji,hes,CLAC,BNIP-H,BB077577,3322401A10Rik, [mus-musculus]

    ATCAY 相关文献