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B18R / B19R  蛋白

All B18R Reagents

表达宿主: Baculovirus-Insect Cells  
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40020-V08B-10
40020-V08B-20
10 µg 
20 µg 
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B18R / B19R 相关信号通路

B18R / B19R 相关蛋白、抗体、cDNA基因、ELISA试剂盒

B18R / B19R 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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B18R / B19R 概述&蛋白信息

B18R / B19R 研究背景

B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (Western Reserve)strain of vaccinia virus. It is also known as B19R in the Copenhagen strain of Vaccinia. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R has a broad species specificity. It has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. It has been shown that secreted B18R binds to uninfected and infected cells. It presents at the cell surface and protects cells from the antiviral state induced by IFN-alpha and IFN-beta. Binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.

B18R / B19R 别称

CD317,TETHERIN, [homo-sapiens]
VACWR199, [Vaccinia virus]

B18R / B19R 相关文献

  1. I Vancov. et al., 1998, J Gen Virol July. 79 (7): 1647-9.
  2. Colamonici OR. et al., 1995, J Biol Chem. 270 (27): 15974-8.
  3. Goebel SJ. et al., 1990, Virology 179: 247-66.
  4. Goebel SJ. et al., 2010, J Cell Biol. 190 (4): 533-9.
请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”