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B2M / Beta-2-microglobulin 抗体, 兔多抗, 抗原亲和纯化

  • B2M / Beta-2-microglobulin Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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小鼠 B2M 抗体产品信息
免疫原:Recombinant Mouse B2M / Beta-2-microglobulin protein (Catalog#50957-M08H)
克隆号:
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS with 5% trehalose
抗体制备方法:Produced in rabbits immunized with purified, recombinant Mouse B2M / Beta-2-microglobulin (rM B2M / Beta-2-microglobulin; Catalog#50957-M08H; P01887; Met1-Met119). B2M / Beta-2-microglobulin specific IgG was purified by Mouse B2M / Beta-2-microglobulin affinity chromatography.
小鼠 B2M 抗体IHC实验图片
B2M / Beta-2-microglobulin Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse B2M in mouse skin with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other B2M 抗体 Products
Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Beta-2 microglobulin/B2M 研究背景

B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.

小鼠 Beta-2 microglobulin/B2M 参考资料
  • Poulik MD, et al. (1979) Beta 2-Microglobulin: methods and clinical applications. CRC Ctit Rev Clin Lab Sci. 10(3): 225-45.
  • Poulik MD, et al. (1975) Beta2-Microglobulins. Contemp Top Mol Immunol. 4: 157-204.
  • Berggard I. (1976) Beta2-Microglobulins: isolation, properties, and distribution. Fed Proc. 35(5): 1167-70.
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    货号: 50957-RP02-200
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