快速订购

狗 BLyS / TNFSF13B / BAFF 蛋白 (Fc 标签)

  • TNFSF13B protein SDS-PAGE
产品数据评论相关产品实验方法
 TNFSF13B 蛋白产品信息
分子别称:BLyS, TNFSF13B, BAFF
蛋白构建:A DNA sequence encoding the canine TNFSF13B (NP_001155182.1) (Ala143-Leu292) was expressed with the Fc region of human IgG1 at the N-terminus.
分子种属:Canine
表达宿主:Human Cells
运输说明:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
 TNFSF13B 蛋白质控检测
纯度:> 90 % as determined by SDS-PAGE.
内毒素:<1.0 EU per μg protein as determined by the LAL method.
稳定性:Samples are stable for up to twelve months from date of receipt at -70℃
预测N端:Glu
分子量:The recombinant canine TNFSF13B consists 412 amino acids and predicts a molecular mass of 45.5 kDa.
缓冲液:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
 TNFSF13B 蛋白使用指导
储存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶条件:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
 TNFSF13B 蛋白SDS-PAGE
TNFSF13B protein SDS-PAGE

TNFSF13B 相关信号通路

Other TNFSF13B 蛋白 Products
BAFF/BLyS/TNFSF13B 研究背景

B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. Thus, it acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). BLyS as an attractive therapeutic target in human rheumatic diseases. The ability of BLyS to regulate both the size and repertoire of the peripheral B cell compartment raises the possibility that BLyS and antagonists thereof may form the basis of a therapeutic trichotomy. As an agonist, BLyS protein may enhance humoral immunity in congenital or acquired immunodeficiencies such as those resulting from viral infection or cancer therapy.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 BAFF/BLyS/TNFSF13B 参考资料
  • Nardelli B, et al. (2002) B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases. Leuk Lymphoma. 43(7): 1367-73.
  • Stohl W. (2006) Therapeutic targeting of B lymphocyte stimulator (BLyS) in the rheumatic diseases. Endocr Metab Immune Disord Drug Targets. 6(4): 51-8.
  • Cancro MP, et al. (2009) The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. J Clin Invest. 119(5): 1066-73.
  • Product nameProduct name
    Size / Price
    货号: 70112-D01H-50
    目录价: 
    单价:      (You Save: )

    Datasheet & Documentation

    Contact Us
    产品数据可能随批次变化,最新数据请详见随货说明书。
    请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”