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C8A  蛋白,抗体,试剂盒,cDNA克隆

C8A 相关研究领域

C8A 相关信号通路

    C8A 概述&蛋白信息

    C8A 研究背景

    亚单位结构: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. {ECO:0000269|PubMed:17692377, ECO:0000269|PubMed:18440555, ECO:0000269|PubMed:7440581}.
    亚细胞定位: Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells.
    相关疾病 : DISEASE: Complement component 8 deficiency, 1 (C8D1) [MIM:613790]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    相似的序列: Belongs to the complement C6/C7/C8/C9 family. {ECO:0000305}.; Contains 1 EGF-like domain. {ECO:0000305}.; Contains 1 LDL-receptor class A domain. {ECO:0000255|PROSITE-ProRule:PRU00124}.; Contains 1 MACPF domain. {ECO:0000255|PROSITE-ProRule:PRU00745}.; Contains 2 TSP type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00210}.
    General information above from UniProt

    C8A 别称

    C8A 相关文献

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