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CD112/Nectin-2/PVRL2  蛋白，抗体，试剂盒，cDNA克隆

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CD112/Nectin-2/PVRL2 相关研究领域

CD112/Nectin-2/PVRL2 相关信号通路

    CD112/Nectin-2/PVRL2 概述&蛋白信息

    CD112/Nectin-2/PVRL2 研究背景

    基因概述: This PVRL2 gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. Nectin-2 is one of the plasma membrane components of adherens junctions. Nectin-2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    General information above from NCBI
    亚单位结构: Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses. {ECO:0000250, ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:15607800, ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:22927415}.
    亚细胞定位: Cell membrane; Single-pass type I membrane protein.
    组织特异性: Ubiquitous.
    相似的序列: Belongs to the nectin family. {ECO:0000305}.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

    CD112/Nectin-2/PVRL2 别称

    CD112/Nectin-2/PVRL2 相关文献

  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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