Nectin-2 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Nectin-2 reagents are produced in house and quality controlled, including 12 Nectin-2 Antibody, 2 Nectin-2 ELISA, 39 Nectin-2 Gene, 2 Nectin-2 IP Kit, 6 Nectin-2 Lysate, 6 Nectin-2 Protein, 3 Nectin-2 qPCR. All Nectin-2 reagents are ready to use.

Nectin-2 Protein (6)

Nectin-2 Antibody (12)

Nectin-2 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

Nectin-2 cDNA Clone (39)

NM_001042724.1

克隆载体 cDNA 产品

In lentiviral vector

NM_008990.3

克隆载体 cDNA 产品

In lentiviral vector

NM_001012064.1

克隆载体 cDNA 产品

In lentiviral vector

Nectin-2 Lysate (6)

Nectin-2 分子背景

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Nectin-2 参考文献

  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.