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IL3RA/CD123  蛋白,抗体,试剂盒,cDNA克隆

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表达宿主: Human Cells  
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10518-H08H-50
10518-H08H-20
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20 µg 
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描述: Active  
表达宿主: Human Cells  
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10518-H03H-50
10518-H03H-20
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20 µg 
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表达宿主: Human Cells  
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50810-M08H-50
50810-M08H-100
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100 µg 
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表达宿主: Human Cells  
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50810-M02H-20
50810-M02H-100
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100 µg 
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表达宿主: Human Cells  
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70077-D08H-20
70077-D08H-10
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10 µg 
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IL3RA/CD123 相关研究领域

IL3RA/CD123 相关信号通路

    IL3RA/CD123 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    IL3RA/CD123 概述&蛋白信息

    IL3RA/CD123 研究背景

    基因概述: The protein encoded by IL3RA gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. IL3RA gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    亚单位结构: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.
    结构域: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; The box 1 motif is required for JAK interaction and/or activation.
    亚细胞定位: Membrane; Single-pass type I membrane protein.
    相似的序列: Belongs to the type I cytokine receptor family. Type 5 subfamily. {ECO:0000305}.
    General information above from UniProt

    Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and / or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity.

    IL3RA/CD123 别称

    IL3R,CD123,IL3RX,IL3RY,IL3RAY,hIL-3Ra, [homo-sapiens]
    CD123,hIL-3Ra,IL3R,IL3RA,IL3RAY,IL3RX,IL3RY,MGC34174,RP11-261P4.2, [human]
    CD123,CDw123,Il3ra,SUT-1, [mouse]
    CD123,SUT-1,CDw123, [mus-musculus]

    IL3RA/CD123 相关文献

  • Del Giudice I, et al. (2004) The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica. 89(3): 303-8.
  • Du X, et al. (2007) New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. J Immunother. 30(6): 607-13.
  • Yue LZ, et al. (2010) Expression of CD123 and CD114 on the bone marrow cells of patients with myelodysplastic syndrome. Chin Med J (Engl). 123(15): 2034-2037.
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