CD16 / FCGR3 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD16 / FCGR3 reagents are produced in house and quality controlled, including 27 CD16 / FCGR3 Antibody, 1 CD16 / FCGR3 ELISA, 26 CD16 / FCGR3 Gene, 1 CD16 / FCGR3 IP Kit, 4 CD16 / FCGR3 Lysate, 6 CD16 / FCGR3 Protein, 1 CD16 / FCGR3 qPCR. All CD16 / FCGR3 reagents are ready to use.

CD16 / FCGR3 分子背景

Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.

CD16 / FCGR3 参考文献

  • Edberg JC, et al. (2002) Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus. Arthritis Rheum. 46(8): 2132-40.
  • Li P, et al. (2002) Recombinant CD16A-Ig forms a homodimer and cross-blocks the ligand binding functions of neutrophil and monocyte Fcgamma receptors. Mol Immunol. 38(7): 527-38.
  • Li P, et al. (2007) Affinity and kinetic analysis of Fcgamma receptor IIIa (CD16a) binding to IgG ligands. J Biol Chem. 282(9): 6210-21.