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CD166/ALCAM  蛋白

All CD166 Reagents

表达宿主: Human Cells  
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10045-H08H-100
10045-H08H-200
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表达宿主: Human Cells  
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50005-M03H-50
50005-M03H-100
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100 µg 
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表达宿主: Human Cells  
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50005-M08H-50
50005-M08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
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80221-R08H-50
80221-R08H-100
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表达宿主: Human Cells  
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80221-R02H-50
80221-R02H-100
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表达宿主: Human Cells  
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90227-C02H-100
90227-C02H-50
100 µg 
50 µg 
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表达宿主: Human Cells  
  • Slide 1
90227-C08H-100
90227-C08H-200
100 µg 
200 µg 
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CD166/ALCAM 相关信号通路

CD166/ALCAM 相关蛋白、抗体、cDNA基因、ELISA试剂盒

CD166/ALCAM 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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CD166/ALCAM 概述&蛋白信息

CD166/ALCAM 研究背景

基因概述: This ALCAM gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
General information above from NCBI
结构域: The CD6 binding site is located in the N-terminal Ig-like domain.
亚细胞定位: Membrane; Single-pass type I membrane protein.
组织特异性: Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.
相似的序列: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.C
General information above from UniProt

Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.

CD166/ALCAM 别称

CD166/ALCAM 相关文献

  • Swart GW. (2002) Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration. Eur J Cell Biol. 81(6): 313-21.
  • Fujiwara H, et al. (2003) Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166). J Clin Endocrinol Metab. 88(7): 3437-43.
  • Jezierska A, et al. (2006) ALCAM/CD166 protects breast cancer cells against apoptosis and autophagy. Med Sci Monit. 12(8): BR263-73.
  • Kahlert C, et al. (2009) Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. Br J Cancer. 101(3): 457-64.
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