All CD2 reagents are produced in house and quality controlled, including 22 CD2 Antibody, 53 CD2 Gene, 7 CD2 Lysate, 7 CD2 Protein, 3 CD2 qPCR. All CD2 reagents are ready to use.
Recombinant CD2 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc.
CD2antibodies are validated with different applications, which are FCM, WB, ELISA, IHC-P.
CD2cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.