CD2 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD2 reagents are produced in house and quality controlled, including 22 CD2 Antibody, 53 CD2 Gene, 8 CD2 Lysate, 8 CD2 Protein, 3 CD2 qPCR. All CD2 reagents are ready to use.

CD2 Protein (8)

CD2 Antibody (22)

CD2 cDNA Clone (53)

NM_001767.3

克隆载体 cDNA 产品

In lentiviral vector

NM_013486.2

克隆载体 cDNA 产品

In lentiviral vector

NM_012830.1

克隆载体 cDNA 产品

In lentiviral vector

NM_001195473.1

克隆载体 cDNA 产品

In lentiviral vector

NM_001195473.1

克隆载体 cDNA 产品

CD2 Lysate (8)

CD2 分子背景

T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.

CD2 参考文献

  • Yang JJ, et al. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr Protein Pept Sci. 2(1): 1-17.
  • Wilkins AL, et al. (2003) Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design. Curr Protein Pept Sci. 4(5): 367-73.
  • McNerney ME, et al. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 298: 91-120.