All CD20 reagents are produced in house and quality controlled, including 13 CD20 Antibody, 52 CD20 Gene, 3 CD20 Lysate, 4 CD20 Protein, 2 CD20 qPCR. All CD20 reagents are ready to use.
Recombinant CD20 proteins are expressed by HEK293 Cells, E. coli with fusion tags as C-His, N-mouse IgG1-Fc, N-His, N-TrxA.
CD20antibodies are validated with different applications, which are WB, ELISA, IHC-P, FCM.
CD20cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD20 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: HEK293 Cells
CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.