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CD226/DNAM-1/PTA1  蛋白,抗体,试剂盒,cDNA克隆

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CD226/DNAM-1/PTA1 相关研究领域

CD226/DNAM-1/PTA1 相关信号通路

    CD226/DNAM-1/PTA1 概述&蛋白信息

    CD226/DNAM-1/PTA1 研究背景

    基因概述: OMIM - description for CD226 (DNAM-1):
    General information above from NCBI
    亚单位结构: Interacts with PVR and PVRL2. {ECO:0000269|PubMed:15039383, ECO:0000269|PubMed:15607800}.
    亚细胞定位: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
    组织特异性: Expressed by peripheral blood T-lymphocytes. {ECO:0000269|PubMed:8673704}.
    相似的序列: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD226, also known as PTA1 or DNAM-1, is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. High rate of CD226 (Cluster of Differentiation 226) is found on the surface of natural killer cells, platelets, monocytes and a subset of T cells. CD226 have binding sites with CD112 and CD155 and mediate cellular adhesion to other cells containing its ligands.

    Immune Checkpoint
    Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies
    Immune Checkpoint Proteins
    Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CD226/DNAM-1/PTA1 别称

    CD226/DNAM-1/PTA1 相关文献

  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
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