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CD23/FCER2  蛋白,抗体,试剂盒,cDNA克隆

表达宿主: Human Cells  
10261-H07H-50
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80208-R01H-50
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CD23/FCER2 相关研究领域

CD23/FCER2 相关信号通路

    CD23/FCER2 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    CD23/FCER2 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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    CD23/FCER2 概述&蛋白信息

    CD23/FCER2 研究背景

    基因概述: The protein encoded by this FCER2 gene is a B-cell specific antigen, and a low-affinity receptor for IgE. CD23 has essential roles in B cell growth and differentiation, and the regulation of IgE production. CD23 also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
    General information above from NCBI
    亚单位结构: Homotrimer. {ECO:0000269|PubMed:16172256, ECO:0000269|PubMed:16765898}.
    亚细胞定位: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.
    翻译后修饰: N- and O-glycosylated.; The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
    相似的序列: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.
    General information above from UniProt

    Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor).

    CD23/FCER2 别称

    CD23/FCER2 相关文献

  • Aubry JP, et al. (1992) CD21 is a ligand for CD23 and regulates IgE production. Nature. 358(6386): 505-7.
  • Punnonen J, et al. (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A. 90(8): 3730-4.
  • Yu P, et al. (1994) Negative feedback regulation of IgE synthesis by murine CD23. Nature. 369(6483): 753-6.
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