BCAM (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All BCAM reagents are produced in house and quality controlled, including 8 BCAM Antibody, 2 BCAM ELISA, 39 BCAM Gene, 1 BCAM IP Kit, 5 BCAM Lysate, 5 BCAM Protein, 3 BCAM qPCR. All BCAM reagents are ready to use.

BCAM Protein (5)

BCAM Antibody (8)

BCAM ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

BCAM cDNA Clone (39)

NM_005581.3

克隆载体 cDNA 产品

In lentiviral vector

NM_020486.2

克隆载体 cDNA 产品

In lentiviral vector

NM_031752.2

克隆载体 cDNA 产品

In lentiviral vector

BCAM Lysate (5)

BCAM 分子背景

The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.

BCAM 参考文献

  • Kikkawa Y, et al. (2005) Review: Lutheran/B-CAM: a laminin receptor on red blood cells and in various tissues. Connect Tissue Res. 46 (4-5): 193-9.
  • El Nemer W, et al. (2007) Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell alpha4beta1 integrin: role in adhesion of sickle red blood cells to endothelial cells. Blood. 109 (8): 3544-51.
  • Colin Y, et al. (2008) Red cell and endothelial Lu/BCAM beyond sickle cell disease. Transfus Clin Biol. 15 (6): 402-5.
  • El Nemer W, et al. (2008) Role of Lu/BCAM in abnormal adhesion of sickle red blood cells to vascular endothelium. Transfus Clin Biol. 15 (1-2): 29-33.