CD28 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD28 reagents are produced in house and quality controlled, including 14 CD28 Antibody, 1 CD28 ELISA, 52 CD28 Gene, 9 CD28 Lysate, 9 CD28 Protein, 3 CD28 qPCR. All CD28 reagents are ready to use.

CD28 Protein (9)

CD28 Antibody (14)

CD28 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

CD28 cDNA Clone (52)

NM_006139.2

克隆载体 cDNA 产品

In lentiviral vector

NM_007642.4

克隆载体 cDNA 产品

In lentiviral vector

NM_013121.1

克隆载体 cDNA 产品

In lentiviral vector

NM_001287333.1

克隆载体 cDNA 产品

In lentiviral vector

CD28 Lysate (9)

CD28 分子背景

CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

CD28 参考文献

  • Keir ME, et al. (2005) The B7/CD28 costimulatory family in autoimmunity. Immunol Rev. 204: 128-43.
  • Sansom DM, et al. (2006) The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev. 212: 131-48.
  • Bjrgo E, et al. (2010) Novel mechanism of signaling by CD28. Immunol Lett. 129(1): 1-6.