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CD33/Siglec-3  蛋白,抗体,试剂盒,cDNA克隆

表达宿主: Human Cells  
12238-H05H-50
12238-H05H-100
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100 µg 
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表达宿主: Human Cells  
12238-HCCH-50
12238-HCCH-200
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200 µg 
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表达宿主: Human Cells  
12238-H08H-50
12238-H08H-100
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100 µg 
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表达宿主: Human Cells  
50712-MCCH-50
50712-MCCH-200
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200 µg 
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表达宿主: Human Cells  
50712-M02H-50
50712-M02H-100
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100 µg 
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表达宿主: Human Cells  
50712-M08H-50
50712-M08H-20
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20 µg 
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表达宿主: Human Cells  
90303-C08H-50
90303-C08H-100
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CD33/Siglec-3 相关研究领域

CD33/Siglec-3 相关信号通路

    CD33/Siglec-3 概述&蛋白信息

    CD33/Siglec-3 研究背景

    亚单位结构: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. {ECO:0000269|PubMed:10206955, ECO:0000269|PubMed:10556798}.
    结构域: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    亚细胞定位: Cell membrane; Single-pass type I membrane protein.
    组织特异性: Monocytic/myeloid lineage cells.
    翻译后修饰: Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. {ECO:0000269|PubMed:10206955, ECO:0000269|PubMed:10556798}.
    相似的序列: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. {ECO:0000305}.; Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CD33/Siglec-3 别称

    CD33,FLJ00391,gp67,SIGLEC3,SIGLEC-3,P67, [human]
    CD33,Siglec-3,gp67, [mouse]

    CD33/Siglec-3 相关文献

  • Simmons D, et al. (1988) Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol. 141(8): 2797-800.
  • Ulyanova T, et al. (1999) The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol. 29(11): 3440-9.
  • Freeman SD, et al. (1995) Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 85(8): 2005-12.
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