CD33 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD33 reagents are produced in house and quality controlled, including 19 CD33 Antibody, 39 CD33 Gene, 1 CD33 IP Kit, 10 CD33 Lysate, 10 CD33 Protein, 2 CD33 qPCR. All CD33 reagents are ready to use.

CD33 Protein (10)

CD33 Antibody (19)

CD33 cDNA Clone (39)

BC028152

克隆载体 cDNA 产品

In lentiviral vector

NM_021293.3

克隆载体 cDNA 产品

In lentiviral vector

XM_001114616.2

克隆载体 cDNA 产品

In lentiviral vector

CD33 Lysate (10)

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CD33 分子背景

Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.

CD33 参考文献

  • Simmons D, et al. (1988) Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol. 141(8): 2797-800.
  • Ulyanova T, et al. (1999) The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol. 29(11): 3440-9.
  • Freeman SD, et al. (1995) Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 85(8): 2005-12.