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CD38/ADPRC1  蛋白,抗体,试剂盒,cDNA克隆

表达宿主: Human Cells  
  • Slide 1
10818-H08H-10
10818-H08H-20
10818-H08H-50
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表达宿主: Human Cells  
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10818-H32H-10
10818-H32H-20
10818-H32H-50
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表达宿主: Human Cells  
  • Slide 1
50191-M08H-10
50191-M08H-20
50191-M08H-50
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表达宿主: Human Cells  
  • Slide 1
80229-R02H-10
80229-R02H-20
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表达宿主: Human Cells  
  • Slide 1
80229-R08H-10
80229-R08H-20
10 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
90050-C02H-10
90050-C02H-20
90050-C02H-50
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表达宿主: Human Cells  
  • Slide 1
90050-C08H-10
90050-C08H-20
10 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
65003-T08H-10
65003-T08H-20
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CD38/ADPRC1 相关信号通路

CD38/ADPRC1 相关蛋白、抗体、cDNA基因、ELISA试剂盒

CD38/ADPRC1 概述&蛋白信息

CD38/ADPRC1 研究背景

基因概述: CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling.
General information above from NCBI
催化活性: NAD(+) + H(2)O = ADP-ribose + nicotinamide.
酶调控: ATP inhibits the hydrolyzing activity.
亚细胞定位: Membrane; Single-pass type II membrane protein.
组织特异性: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
发育阶段: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
相似的序列: Belongs to the ADP-ribosyl cyclase family.
General information above from UniProt

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.

CD38/ADPRC1 别称

T10,ADPRC1, [homo-sapiens]
CD38,T10, [human]
CD38,Cd38-rs1, [mouse]
ADPRC1,Cd38-rs1, [mus-musculus]

CD38/ADPRC1 相关文献

  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
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