快速订购

狗 CD3e / CD3 epsilon 蛋白 (Fc 标签)

  • CD3E protein SDS-PAGE
产品数据评论相关产品实验方法
 CD3E 蛋白产品信息
分子别称:CD3e, CD3 epsilon
蛋白构建:A DNA sequence encoding the canine CD3E (NP_001003379.1) (Met1-Leu122) was expressed with the Fc region of human IgG1 at the C-terminus.
分子种属:Canine
表达宿主:Human Cells
运输说明:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
 CD3E 蛋白质控检测
纯度:> 85 % as determined by SDS-PAGE.
内毒素:<1.0 EU per μg protein as determined by the LAL method.
稳定性:Samples are stable for up to twelve months from date of receipt at -70℃
预测N端:Gln 22
分子量:The recombinant canine CD3E consists 339 amino acids and predicts a molecular mass of 38.2 kDa.
缓冲液:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
 CD3E 蛋白使用指导
储存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶条件:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
 CD3E 蛋白SDS-PAGE
CD3E protein SDS-PAGE

CD3E 相关信号通路

Other CD3E 蛋白 Products
描述:   
表达宿主: Human Cells  
  • Slide 1
10977-H08H-50
10977-H08H-20
50 µg 
20 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
10977-H03H-50
10977-H03H-20
50 µg 
20 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
80452-R02H-20
80452-R02H-100
20 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
90047-C03H-20
90047-C03H-100
20 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
90047-C02H-50
90047-C02H-20
50 µg 
20 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
90047-C08H-50
90047-C08H-20
50 µg 
20 µg 
Add to Cart
CD3e/CD3 epsilon 研究背景

T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 CD3e/CD3 epsilon 参考资料
  • Fischer A, et al. (2005) CD3 deficiencies. Curr Opin Allergy Clin Immunol. 5(6): 491-5.
  • Wang Y, et al. (2009) A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol. 7(12): e1000253.
  • Martnez-Martn N, et al. (2009) Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon. Sci Signal. 2(83): ra43.
  • Deford-Watts LM, et al. (2009) The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions. J Immunol. 183(2): 1055-64.
  • Product nameProduct name
    Size / Price
    货号: 70106-D02H-20
    目录价: 
    单价:      (You Save: )

    Datasheet & Documentation

    Contact Us
    产品数据可能随批次变化,最新数据请详见随货说明书。
    请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”