CD40 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD40 reagents are produced in house and quality controlled, including 27 CD40 Antibody, 2 CD40 ELISA, 40 CD40 Gene, 1 CD40 IP Kit, 11 CD40 Lysate, 15 CD40 Protein, 3 CD40 qPCR. All CD40 reagents are ready to use.

CD40 Protein (15)

CD40 Antibody (27)

CD40 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

CD40 cDNA Clone (40)

NM_001250.4

克隆载体 cDNA 产品

In lentiviral vector

NM_152854.2

In lentiviral vector

NM_134360.1

克隆载体 cDNA 产品

In lentiviral vector

XM_001104333.2

克隆载体 cDNA 产品

In lentiviral vector

CD40 Lysate (11)

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CD40 分子背景

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

CD40 参考文献

  • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
  • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
  • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
  • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
  • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.