CD46 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD46 reagents are produced in house and quality controlled, including 8 CD46 Antibody, 29 CD46 Gene, 1 CD46 IP Kit, 1 CD46 Lysate, 1 CD46 Protein, 1 CD46 qPCR. All CD46 reagents are ready to use.

CD46 Protein (1)

CD46 Antibody (8)

CD46 cDNA Clone (29)

BC030594

克隆载体 cDNA 产品

In lentiviral vector

CD46 qPCR Primer (1)

CD46 Lysate (1)

更多受客户欢迎的产品

CD46 分子背景

CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.

CD46 参考文献

  • Lublin D.M., et al.,(1988), Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J. Exp. Med. 168:181-194.
  • Purcell D.F., et al., (1991), Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.Immunogenetics 33:335-344.
  • Post T.W., et al.,(1991), Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.J. Exp. Med. 174:93-102.