CD47 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD47 reagents are produced in house and quality controlled, including 15 CD47 Antibody, 52 CD47 Gene, 13 CD47 Lysate, 14 CD47 Protein, 2 CD47 qPCR. All CD47 reagents are ready to use.

CD47 Protein (14)

CD47 Antibody (15)

CD47 cDNA Clone (52)

BC010016

克隆载体 cDNA 产品

In lentiviral vector

NM_001777.3

克隆载体 cDNA 产品

In lentiviral vector

XM_006521811.2
NM_019195.2

克隆载体 cDNA 产品

In lentiviral vector

XM_005548232.2

克隆载体 cDNA 产品

CD47 Lysate (13)

CD47 分子背景

CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

CD47 参考文献

  • Brown EJ, et al. (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11(3): 130-5.
  • Oldenborg PA. (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma. 45(7): 1319-27.
  • Kaczorowski DJ, et al. (2007) Targeting CD47: NO limit on therapeutic potential. Circ Res. 100(5): 602-3.