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CD59a / Protectin  蛋白,抗体,试剂盒,cDNA克隆

表达宿主: Human Cells  
  • Slide 1
50724-M08H-50
50724-M08H-20
50 µg 
20 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
50724-M02H-50
50724-M02H-20
50 µg 
20 µg 
Add to Cart

CD59a / Protectin 相关研究领域

CD59a / Protectin 相关信号通路

    CD59a / Protectin 概述&蛋白信息

    CD59a / Protectin 研究背景

    Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins.It was found that the CD59/Protectin antigen is a small protein sometimes associated with larger components (45 and 80 kD) in urine. CD59/Protectin antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor; it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria.

    CD59a / Protectin 别称

    AA987121,protectin,RP24-297H17.1,Cd59, [human]

    CD59a / Protectin 相关文献

  • Huang Y, et al. (2006) Defining the CD59-C9 binding interaction. J Biol Chem. 281 (37): 27398-404.
  • Sawada R, et al. (1990) Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes. DNA Cell Biol. 9(3): 213-20.
  • Philbrick WM, et al. (1990) The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility. Eur J Immunol. 20(1): 87-92.
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