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CD74 抗体, 鼠单抗

  • CD74 Antibody, Mouse MAb, Immunochemistry
  • CD74 Antibody, Mouse MAb, Immunochemistry
  • CD74 Antibody, Mouse MAb, Immunochemistry
  • CD74 Antibody, Mouse MAb, Flow Cytometry
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 CD74 抗体产品信息
免疫原:Recombinant Human CD74 protein (Catalog#11091-H07H)
克隆号:01
Ig 类型:Mouse IgG1
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS
抗体制备方法:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD74 (rh CD74; Catalog#11091-H07H; NP_005219; Met668-Ala1210). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
 CD74 抗体IHC实验图片
CD74 Antibody, Mouse MAb, Immunochemistry
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Caption:
Immunochemical staining of human CD74 in human appendix with mouse monoclonal antibody (1µg/mL, formalin-fixed paraffin embedded sections).
CD74 Antibody, Mouse MAb, Immunochemistry
[点击查看大图]
Caption:
Immunochemical staining of human CD74 in human colon carcinoma with mouse monoclonal antibody (1µg/mL, formalin-fixed paraffin embedded sections).
CD74 Antibody, Mouse MAb, Immunochemistry
[点击查看大图]
Caption:
Immunochemical staining of human CD74 in human tonsil with mouse monoclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
 CD74 抗体FC实验图片
CD74 Antibody, Mouse MAb, Flow Cytometry
[点击查看大图]
Caption:
Flow cytometric analysis of Human CD74 expression on human whole blood lymphocytes. Cells were stained with purified anti-Human CD74, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
Other CD74 抗体 Products
CD74 研究背景

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD74, also known as HLA class2 histocompatibility antigen gamma chain and HLA-DR antigens-associated invariant chain, is a polypeptide involved in the formation and transport of MHC class2 protein. CD74 is expressed by B cells, macrophages, and Reed-Sternberg cells. When MHC class 2 protein was in the rough ER, its peptide-binding cleft was blocked by CD74 to prevent it from interacting with the endogenous peptides. CD74 also serves to facilitate MHC class2's export from ER.

 CD74 参考资料
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Moynes R, et al. (1997) A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. Cancer. 79 (11): 2115-24.
  • Gabrielle FA, et al. (2008) Regulation of dendritic cell migration by CD74, the MHC class 2-associated invariant chain. Science. 322 (5908): 1705-10.
  • Leng L, et al. (2003) MIF signal transduction initiated by binding to CD74. JEM.197 (11): 1467-76.
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    货号: 11091-MM01-200
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    请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”