CD8 alpha (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CD8 alpha reagents are produced in house and quality controlled, including 41 CD8 alpha Antibody, 3 CD8 alpha ELISA, 53 CD8 alpha Gene, 7 CD8 alpha Lysate, 9 CD8 alpha Protein, 3 CD8 alpha qPCR. All CD8 alpha reagents are ready to use.

CD8 alpha Protein (9)

CD8 alpha Antibody (41)

CD8 alpha ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(3)

CD8 alpha cDNA Clone (53)

NM_001768.5

克隆载体 cDNA 产品

In lentiviral vector

NM_001081110.2

克隆载体 cDNA 产品

In lentiviral vector

NM_031538.2

克隆载体 cDNA 产品

In lentiviral vector

XM_005575362.1

In expression vector

EF492056.1

克隆载体 cDNA 产品

In lentiviral vector

CD8 alpha Lysate (7)

CD8 alpha 分子背景

T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

CD8 alpha 参考文献

    References Devine, L. et al., 2000, J Immunol. 164 (2): 833-8. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.