快速订购

CDCP1 抗体, 兔多抗, 抗原亲和纯化

  • CDCP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • CDCP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
产品数据评论相关产品实验方法
小鼠 CDCP1 抗体产品信息
免疫原:Recombinant Mouse CDCP1 protein (Catalog#51110-M08H)
克隆号:
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS with 5% trehalose
抗体制备方法:Produced in rabbits immunized with purified, recombinant Mouse CDCP1 (rM CDCP1; Catalog#51110-M08H; Q5U462; Met1-Leu666). CDCP1 specific IgG was purified by Mouse CDCP1 affinity chromatography.
小鼠 CDCP1 抗体IHC实验图片
CDCP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of mouse CDCP1 in mouse intestine with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
CDCP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of mouse CDCP1 in mouse lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Other CDCP1 抗体 Products
CDCP1 研究背景

CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and in both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.

小鼠 CDCP1 参考资料
  • Conze T, et al.. (2003) CDCP1 is a novel marker for hematopoietic stem cells. Ann N Y Acad Sci. 996 (1): 222-6.
  • Hooper JD, et al. (2003) Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene. 22(12): 1783-94.
  • Scherl-Mostageer M, et al. (2001) Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene. 20(32):4402-8.
  • Product nameProduct name
    产品数据可能随批次变化,最新数据请详见随货说明书。
    请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”