快速订购

CDK8  蛋白,抗体,试剂盒,cDNA克隆

CDK8 相关研究领域

CDK8 相关信号通路

CDK8 概述&蛋白信息

CDK8 研究背景

催化活性: ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:10993082}.; ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. {ECO:0000269|PubMed:10993082}.
辅因子: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
亚单位结构: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1. {ECO:0000269|PubMed:10024883, ECO:0000269|PubMed:15175163, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:17000779, ECO:0000269|PubMed:21806996, ECO:0000269|PubMed:9734358}.
亚细胞定位: Nucleus {ECO:0000305}.
相似的序列: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

CDK8 别称

K35, [homo-sapiens]

CDK8 相关文献

请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”