CD66b (Protein|Antibody|cDNA Clone|ELISA Kit)

All CD66b reagents are produced in house and quality controlled, including 7 CD66b Antibody, 15 CD66b Gene, 1 CD66b Lysate, 1 CD66b Protein, 1 CD66b qPCR. All CD66b reagents are ready to use.

Recombinant CD66b proteins are expressed by HEK293 Cells with fusion tags as C-His.

CD66b antibodies are validated with different applications, which are FCM, ELISA.

CD66b cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD66b of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

CD66b Protein (1)

Species

CD66b Protein, Human, Recombinant (His Tag)

11729-H08H

Expression host: HEK293 Cells

Human CEACAM8/CD66b/CD67 Protein 9805
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CD66b Antibody (7)

Application Clonality
Host

Anti-CD66b Antibody (PE)

11729-MM04-P

Specificity: Human

Application: FCM

Clonality: MAb

Human CEACAM8/CD66b/CD67 Flow Cytometry (FC) 2547

Anti-CD66b Antibody (FITC)

11729-MM04-F

Specificity: Human

Application: FCM

Clonality: MAb

Human CEACAM8/CD66b/CD67 Flow Cytometry (FC) 2547

Anti-CD66b Antibody

11729-R013

Specificity: Human

Application: ELISA

Clonality: MAb

Anti-CD66b Antibody

11729-MM04

Specificity: Human

Application: ELISA,FCM

Clonality: MAb

Human CEACAM8/CD66b/CD67 Flow Cytometry (FC) 2546

Anti-CD66b Antibody

11729-RP01

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-CD66b Antibody

11729-RP02

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-CD66b Antibody (APC)

11729-MM04-A

Specificity: Human

Application: FCM

Clonality: MAb

Human CEACAM8/CD66b/CD67 Flow Cytometry (FC) 2547
Go

CD66b cDNA Clone (15)

Human
NM_001816.3
BC026263

CD66b qPCR Primer (1)

CD66b Lysate (1)

CEACAM8, also known as CD66b or NCA-95, is a single chain, GPI-anchored, highly glycosylated protein belonging to the carcinoembryonic antigen family. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM8(CD66b) is also an activation marker for human granulocytes. However, its biological functions are largely unknown in eosinophils. It has been reported that CD66b is highly expressed on the surface of human peripheral blood eosinophils isolated from healthy individuals. Engagement of CD66b by mAb or a natural ligand, galectin-3, activated a Src kinase family molecule, hemopoietic cell kinase (Hck), and induced cellular adhesion, superoxide production, and degranulation of eosinophils. CD66b molecules were localized in lipid rafts, and disruption of lipid rafts or removal of the GPI anchor inhibited the adhesion and activation of eosinophils. Importantly, CD66b was constitutively and physically associated with a beta2 integrin, CD11b, and cross-linking of CD66b induced a striking clustering of CD11b molecules. Thus, CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. Binding of exogenous or endogenous carbohydrate ligands(s) to CD66b may be important in the release of proinflammatory mediators by human eosinophils.
Protein
Antibody
Gene
qPCR
Lysate
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