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CLEC5A / MDL1 / MDL-1 抗体, 兔多抗, 抗原亲和纯化

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    大鼠 CLEC5A 抗体产品信息
    免疫原:Recombinant Rat CLEC5A / MDL1 / MDL-1 protein (Catalog#80259-R07H)
    克隆号:
    Ig 类型:Rabbit IgG
    浓度:
    内毒素:
    缓冲液:0.2 μm filtered solution in PBS
    抗体制备方法:Produced in rabbits immunized with purified, recombinant Rat CLEC5A / MDL1 / MDL-1 (rh CLEC5A / MDL1 / MDL-1; Catalog#80259-R07H; F7GAV1; Val30-Lys190). CLEC5A / MDL1 / MDL-1 specific IgG was purified by Rat CLEC5A / MDL1 / MDL-1 affinity chromatography.
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    CLEC5A / MDL1 / MDL-1 研究背景

    CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

    大鼠 CLEC5A / MDL1 / MDL-1 参考资料
  • Chen ST. et al., 2008, Nature. 453 (7195): 672-6.
  • Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
  • Hillier LW. et al., 2003, Nature. 424 (6945): 157-64.
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    货号: 80259-T16-200
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