Anti-CLEC5A Antibody

Cat: 80259-T16

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Anti-CLEC5A Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-CLEC5A Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat CLEC5A
Immunogen
Recombinant Rat CLEC5A / MDL1 / MDL-1 protein (Catalog#80259-R07H)
Preparation
Produced in rabbits immunized with purified, recombinant Rat CLEC5A / MDL1 / MDL-1 (Catalog#80259-R07H; F7GAV1; Val30-Lys190). CLEC5A / MDL1 / MDL-1 specific IgG was purified by Rat CLEC5A / MDL1 / MDL-1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-CLEC5A Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

CLEC5A Background Information

CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Full Name
C-type lectin domain family 5, member A
References
  • Chen ST. et al., 2008, Nature. 453 (7195): 672-6.
  • Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
  • Hillier LW. et al., 2003, Nature. 424 (6945): 157-64.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CLEC5A Antibody Rabbit Monoclonal ELISA 80259-R005
    Anti-CLEC5A Antibody Rabbit Polyclonal ELISA 80259-RP01
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