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CLPS / Colipase 抗体, 兔多抗, 抗原亲和纯化

  • CLPS / Colipase Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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 CLPS 抗体产品信息
免疫原:Recombinant Human CLPS / Colipase protein (Catalog#13631-H08B)
克隆号:
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS with 5% trehalose
抗体制备方法:Produced in rabbits immunized with purified, recombinant Human CLPS / Colipase (rh CLPS / Colipase; Catalog#13631-H08B; P04118; Met1-Gln112). CLPS / Colipase specific IgG was purified by Human CLPS / Colipase affinity chromatography.
 CLPS 抗体IHC实验图片
CLPS / Colipase Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of human CLPS in human pancreas with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to pancreatic acinus.
Other CLPS 抗体 Products
CLPS / Colipase 研究背景

Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural analogies have been recognised between a developmental protein, the pancreatic lipase C-terminal domain, the N-terminal domains of lipoxygenases and the C-terminal domain of alpha-toxin. Colipase can only be detected in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Colipase allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Colipase is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilising as active conformation and considerably increasing the overall hydrophobic binding site.

 CLPS / Colipase 参考资料
  • Davis RC, et al. (1991) Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. Genomics. 10(1):262-5.
  • Lowe ME. (1997) Structure and function of pancreatic lipase and colipase. Annu Rev Nutr. 17: 141-58.
  • Verger R, et al. (1999) Colipase: structure and interaction with pancreatic lipase. Biochim Biophys Acta. 1441(2-3):173-84.
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