Anti-CREB3L1 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human CREB3L1 / OASIS protein (Catalog#12712-H08H)
Produced in rabbits immunized with purified, recombinant Human CREB3L1 / OASIS (rh CREB3L1 / OASIS; Catalog#12712-H08H; Q96BA8-1; Glu396- Ser519). CREB3L1 / OASIS specific IgG was purified by Human CREB3L1 / OASIS affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CREB3L1 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-CREB3L1 Antibody Alternative Names
CREB3L1 Background Information
CREB3L1, also known as OASIS, is a cellular transcription factor synthesized as a membrane-bound precursor. It is a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation. OASIS mRNA expression was detected in pancreatic β-cell lines and rodent islets, and the expression level was up-regulated by ER stress-inducing compounds. CREB3L1 may have a role in pancreas development. CREB3L1 may also play an important role in limiting virus spread by inhibiting proliferation of virus-infected cells. In vitro, CREB3L1 binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. It may play a role in gliosis.
cAMP responsive element binding protein 3-like 1
Denard B. et al., 2011, Cell Host Microbe. 10 (1): 65-74. Debelenko LV. et al., 2011, 50 (12): 1054-62. Vellanki. et al., 2010, Endocrinology. 151 (9): 4146.