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CSF1R / MCSF Receptor / CD115 抗体, 兔多抗, 抗原亲和纯化

  • CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
产品数据评论相关产品实验方法
 CSF1R 抗体产品信息
免疫原:Recombinant Human CSF1R / M-CSFR / CD115 protein (Catalog#10161-H20B2)
克隆号:
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS with 5% trehalose
抗体制备方法:Produced in rabbits immunized with purified, recombinant Human CSF1R / M-CSFR / CD115 (rh CSF1R / M-CSFR / CD115; Catalog#10161-H20B2; NP_005202.2; Lys543-Asp922). CSF1R / M-CSFR / CD115 specific IgG was purified by Human CSF1R / M-CSFR / CD115 affinity chromatography.
 CSF1R 抗体IHC实验图片
CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of human CSF1R in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of human CSF1R in human lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other CSF1R 抗体 Products
反应性: Human  
应用 : FCM  
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10161-MM04-F-25
10161-MM04-F-100
25 Test 
100 Tests 
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反应性: Human  
应用 : ELISA  
    10161-RP03-50
    10161-RP03-200
    10161-RP03-100
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    应用 : FCM  
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    10161-MM04-50
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    10161-MM04-100
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    反应性: Human  
    应用 : ELISA  
      10161-RP01-400
      10161-RP01-200
      10161-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      应用 : ELISA  
        10161-R108-50
        10161-R108-100
        50 µg 
        100 µg 
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        10161-T24-50
        10161-T24-200
        10161-T24-100
        50 µg 
        200 µg 
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        反应性: Human  
        应用 : ELISA  
          10161-R029-50
          10161-R029-100
          50 µg 
          100 µg 
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          反应性: Human  
          应用 : ELISA  
            10161-MM12-50
            10161-MM12-200
            10161-MM12-100
            50 µg 
            200 µg 
            100 µg 
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            反应性: Human  
            应用 : ELISA  
              10161-MM02-50
              10161-MM02-200
              10161-MM02-100
              50 µg 
              200 µg 
              100 µg 
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              反应性: Mouse  
              应用 : ELISA  
                50059-R220-50
                50059-R220-100
                50 µg 
                100 µg 
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                反应性: Mouse  
                应用 : ELISA  
                  50059-RP02-50
                  50059-RP02-200
                  50059-RP02-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  反应性: Mouse  
                  应用 : ELISA  
                  • Slide 1
                  50059-RP01-400
                  50059-RP01-200
                  50059-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  反应性: Rat  
                  应用 : ELISA  
                    80447-T16-50
                    80447-T16-200
                    80447-T16-100
                    50 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    反应性: Rat  
                    应用 : ELISA  
                      80447-RP01-400
                      80447-RP01-200
                      80447-RP01-100
                      400 µg 
                      200 µg 
                      100 µg 
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                      MCSF Receptor/CSF1R/CD115 研究背景

                      M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.

                       MCSF Receptor/CSF1R/CD115 参考资料
                    • Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
                    • Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
                    • Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
                    • Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
                    • Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.
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                      货号: 10161-RP02-50
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                      Datasheet & Documentation

                      产品数据可能随批次变化,最新数据请详见随货说明书。
                      请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”