Casein Kinase 1 alpha (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Casein Kinase 1 alpha reagents are produced in house and quality controlled, including 32 Casein Kinase 1 alpha Gene, 1 Casein Kinase 1 alpha Lysate, 1 Casein Kinase 1 alpha Protein, 2 Casein Kinase 1 alpha qPCR. All Casein Kinase 1 alpha reagents are ready to use.

Casein Kinase 1 alpha 分子背景

Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis.

Casein Kinase 1 alpha 参考文献

  • Dubois, et al.,2002, FEBS Lett. (Netherlands) 517 (1-3): 167-71. 
  • Dubois, T et al.,2001, J. Biol. Chem.(United States) 276 (22): 18757-64.
  • Zhang, Yi et al., 2002, J. Biol. Chem. 277(20): 17706-12.
  • Wang,Z. et al., 2010, Med Sci Monit.16 (8):CR357-64.