IP-10/CXCL10 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All IP-10/CXCL10 reagents are produced in house and quality controlled, including 3 IP-10/CXCL10 Antibody, 1 IP-10/CXCL10 ELISA, 41 IP-10/CXCL10 Gene, 2 IP-10/CXCL10 Protein, 3 IP-10/CXCL10 qPCR. All IP-10/CXCL10 reagents are ready to use.

IP-10/CXCL10 Protein (2)

    IP-10/CXCL10 Antibody (3)

      IP-10/CXCL10 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      IP-10/CXCL10 cDNA Clone (41)

      NM_001565.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_021274.1

      克隆载体 cDNA 产品

      In lentiviral vector

      BC058444.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_139089.1

      克隆载体 cDNA 产品

      In lentiviral vector

      IP-10/CXCL10 分子背景

      (C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10/IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, mixed cryoglobulinemia, Sjögren syndrome, or systemic sclerosis). CXCL10/IP-10 is secreted by several cell types including endothelial cells, fibroblasts, keratinocytes, thyrocytes, preadipocytes, etc. Determination of high level of CXCL10/IP-10 in peripheral fluids is therefore a marker of host immune response.

      IP-10/CXCL10 参考文献

      • O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
      • Swaminathan GJ, et al. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 11(5):521-32.
      • Booth V, et al. (2002) The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 41(33):10418-25.