Anti-GRO Beta / CXCL2 Antibody

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Anti-GRO Beta / CXCL2 Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-GRO Beta / CXCL2 Antibody
经验证的应用
ELISA
交叉反应
Reacts with: Mouse
特异性
Mouse GRO Beta / CXCL2
免疫原
Recombinant Mouse CXCL2/MIP-2 Protein (Catalog#50070-M28E)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CXCL2/MIP-2 (rM CXCL2/MIP-2; Catalog#50070-M28E; P10889-1; Ala28-Asn100).
来源
Monoclonal Rabbit IgG Clone #003
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-GRO Beta / CXCL2 Antibody (Rabbit Monoclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-GRO Beta / CXCL2 Antibody: 别称

Anti-CINC-2a Antibody; Anti-Gro2 Antibody; Anti-GROb Antibody; Anti-Mgsa-b Antibody; Anti-MIP-2 Antibody; Anti-MIP-2a Antibody; Anti-Mip2 Antibody; Anti-Scyb Antibody; Anti-Scyb2 Antibody

GRO Beta / CXCL2 背景信息

Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.
全称
chemokine (C-X-C motif) ligand 2
参考文献
  • Driscoll KE. (2000) TNFalpha and MIP-2: role in particle-induced inflammation and regulation by oxidative stress. Toxicol Lett. 112-113: 177-83.
  • Walpen S, et al. (2001) Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis. FASEB J. 15(3): 571-3.
  • Fahey TJ, et al. (1990) Cytokine production in a model of wound healing: the appearance of MIP-1, MIP-2, cachectin/TNF and IL-1. Cytokine. 2(2): 92-9.
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